The effects of water and alcohol extracts of Aconiti Turber, Arceae Semen, Cocculi Lig￢nam, Myristicae Semen, Sartellariae Radix, and Tiglii Semen on the motility and glucose absorption rates were investigated in the isolated small intestinal strips of rabbit. In addi￢tion to the action of extract on the intestinal motility, the effect of water extract of Arceae Semen on the contractility of uterine muscle strips in rabbit and frog skeletal muscle and heart rate and blood pressure changes after intravenous injection of Arceae Semen extract were also studied.
Motility was recorded on a Physiograph (Narco Biosystem, Four A.) with force trans￢ducer by means of Magnus methods in Lock´s solution and blood pressure was recorded by direct method.
The results are summarized as follows;
1. The motility of isolated uterine and small intestinal muscle strips were increased by treated with extract of Arceae Semen. These effects were blocked by pretreatment of, . atropine but not by hexamethonium.
2. Blood pressure and heart rate were significantly decreased after intravenous adminis￢tration of water extract of Arceae Semen and acetylcholine. These effects were also blocked by premedication of atropine but not hexamethonium.
3. The contractility of frog skeletal muscle could not observed by water extract of Arceae Semen. In the above results, it was suggested that water extract of Arceae Semen may be parasympathomimetic drug which act on the muscarinic recepter.
4. The extract of Aconiti Tuber could not effect on the intestinal motility of rabbit.
5. The motility of intestinal muscle strips were decreased by treated with extracts of myristicae Semen and Sartellariae Radix. These effects were not blocked by atropine, inderal and regitine, and these were not effected on the acetylcholine. It was suggested that these extracts were not related to the action of autonomic nervous system.
6. The motility of small intestine was increased by treated with extracts of Cocculi Lignam and Tiglii Semen. These effects were not blocked by atropine, hexamethonium, regitine and inderal.
7. All of the extracts used this study were not effects on the intestinal glucose absorption.
|